When an unconscious Hercules falls from a waterfall after saving Icarus he washes up near Gorgon Land where he is rescued by Medusa who begins to admire the unconscious boy's face, but after an interruption from Icarus and Pegasus who are looking for him she runs away. Later on after having some one-sided conversations with some statues she finds Hercules' school ID, this causes her to crave a normal life more and more so she beseeches the Olympian Gods to help her, her call is answered by Hades, lord of the dead and Aphrodite, the Goddess of Love. Hades offers her an opportunity to become a human by day in exchange for working for him at night as a monster while Aphrodite offers Medusa special sunglasses that would block her powers, allowing her to interact with the world while still being herself. She ends up taking Hades' offer, thinking nobody could see past her true form. Things go well for her until a chaotic trip to the Pita Pit where at sunset, she starts her transformation and ends up causing a gorgon panic throughout Athens.
Medusa is a very lonely being due to her inability to communicate with others, this is because of her uncontrollable power of turning people into stone. Her only companions are her living snake hair and the many statues that decorate her grove which she usually pretends to talk to in order to lessen her loneliness. She is also very self-conscious as shown when Aphrodite and Hades both made her an offer to allow her to get close to Hercules, she preferred Hades' deal since it would make her human as apposed to Aphrodite's deal which would not change her "ugly" appearance.